Guidance for Human Health Risk Assessments for Pesticides
On this page:
- Exposure assessment
- General guidance
- Guidance for toxicology testing
- Determining data requirements
- Cumulative exposure and risk assessment
Exposure Assessment
- Standard operating procedures for residential pesticide exposure assessment
- Revised methods for worker risk assessment
- Indirect Dietary Residential Exposure Assessment Model (IDREAM) Implementation
- Available information on assessing exposure from pesticides in food—A User’s Guide
- General principles for performing aggregate exposure and risk assessments
- Occupational pesticide handler exposure data
- Occupational pesticide post-application exposure data
- Occupational Pesticide Exposure - Seed Treatment
- Standard operating procedures for ultra-low volume adulticide exposure assessment
General Guidance
- Determination of the appropriate FQPA safety factor(s) in tolerance assessment
- Choosing a percentile of acute dietary exposure as a threshold of regulatory concern
- Guidance for considering and using open literature studies to support human health risk assessment
- Guidance for waiving or bridging of mammalian acute toxicity tests for pesticides and pesticide products
Guidance for Toxicology Testing
- Advances in genetic toxicology and integration of in vivo testing into standard repeat dose studies
- Use of the local lymph node assay and reduced dose protocol for LLNA in assessing pesticide products
- Process for establishing and implementing alternative approaches to traditional in vivo acute toxicity studies
- Acute oral toxicity up-and-down procedure
- Developing a tiered framework for extrapolation modeling
- Alternate testing framework for classification of eye irritation potential of EPA-regulated pesticide products
- Guidance for thyroid assays in pregnant animals, fetuses and post-natal animals, and adult animals
- Developmental neurotoxicity study guidance (NAFTA TWG)
Determining Data Requirements
Cumulative Exposure and Risk Assessment
- Guidance for identifying pesticide chemicals and other substances that have a common mechanism of toxicity
- Guidance on cumulative risk assessment of pesticide chemicals that have a common mechanism of toxicity
- Consideration of the FQPA safety factor and other uncertainty factors in cumulative risk assessment of chemicals sharing a common mechanism of toxicity
- The use of data on cholinesterase inhibition for risk assessments of organophosphorous and carbamate pesticides
- Pesticide Cumulative Risk Assessment: Framework for Screening Analysis