Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock (LockA locked padlock) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Emergency

This is not the current EPA website. To navigate to the current EPA website, please go to www.epa.gov. This website is historical material reflecting the EPA website as it existed on January 19, 2025. This website is no longer updated and links to external websites and some internal pages may not work. More information »

    • Environmental Topics
    • Air
    • Bed Bugs
    • Cancer
    • Chemicals, Toxics, and Pesticide
    • Climate Change
    • Emergency Response
    • Environmental Information by Location
    • Environmental Justice
    • Greener Living
    • Health
    • Land, Waste, and Cleanup
    • Lead
    • Mold
    • Radon
    • Research
    • Science Topics
    • Water Topics
    • A-Z Topic Index
    • Laws & Regulations
    • By Business Sector
    • By Topic
    • Compliance
    • Enforcement
    • Laws and Executive Orders
    • Regulations
    • Report a Violation
    • Environmental Violations
    • Fraud, Waste or Abuse
    • About EPA
    • Our Mission and What We Do
    • Headquarters Offices
    • Regional Offices
    • Labs and Research Centers
    • Planning, Budget, and Results
    • Organization Chart
    • EPA History
    • Staff Directory

Breadcrumb

  1. Home
  2. Air: Fate, Exposure, and Risk Analysis (FERA)

Risk Assessment and Modeling - EPA Risk Assessment Policy, Guidelines, and Related Materials

Risk Assessment and Modeling
  • Overview Air Toxics Risk Assessment
  • Criteria Air Pollutant Risk Assessment
  • Human Exposure Model (HEM)
  • EPA Risk Assessment Policy, Guidelines, and Related Materials

Policies, Guidance and Frameworks

  • Cumulative Risk Assessment
  • Ecological Risk Assessment Framework
  • Human Health Risk Assessment Framework 
  • Metals Risk Assessment Framework
  • Probabilistic Analysis Policy 
  • Risk Characterization Guidance
  • Risk Characterization Handbook, with Policy
  • Cancer Risk Assessment Guidelines- Implementation
  • Supplemental Guidance for Early-Life Exposure to Carcinogens

Guidelines

  • Cancer Risk Assessment Guidelines
  • Cancer Risk Assessment Guidelines - Implementation
  • Chemical Mixtures Risk Assessment Guidelines
  • Chemical Mixtures Risk Assessment, Supplementary Guidance
  • Developmental Risk Assessment Guidelines
  • Ecological Risk Assessment Guidelines
  • Neurotoxicity Risk Assessment Guidelines
  • Reproductive Toxicity Risk Assessment Guidelines

Methods

  • Methods for Derivation of RfCs & Application of Inhalation Dosimetry (USEPA 1994)
  • Report: Advances in Inhalation Dosimetry of Gases/Vapors with Portal of Entry Effects in Upper Respiratory Tract (USEPA 2009)
  • Report: Advances in Inhalation Dosimetry for Gases with Lower Respiratory Tract and Systemic Effects (USEPA 2011)
  • Report: Advances in Inhalation Gas Dosimetry for Derivation of a Reference Concentration (RfC) and Use in Risk Assessment (USEPA 2012)

Air: Fate, Exposure, and Risk Analysis (FERA)

  • Total Risk Integrated Methodology (TRIM)
    • TRIM.FaTE
    • TRIM.Expo
    • TRIM.Risk
    • Peer Review and Publications
  • Multimedia Fate and Transport Modeling
    • TRIM.FaTE
    • Other Models and Related Information
  • Human Exposure Assessment and Modeling
    • Criteria Air Pollutant Exposure Assessment
    • Databases to Support Exposure Modeling
    • Air Pollutants Exposure Model (APEX/ TRIM.Expo Inhalation)
    • Hazardous Air Pollutant Exposure Model (HAPEM)
    • Other Models and Exposure-Related Information
  • Risk Assessment and Modeling
    • Air Toxics Risk Assessment
    • Criteria Air Pollutant Risk Assessment
    • Human Exposure Model (HEM)
    • EPA Risk Assessment Policy, Guidelines, and Related Materials
Contact Us about FERA
Contact Us about FERA to ask a question, provide feedback, or report a problem.
Last updated on May 15, 2024
  • Assistance
  • Ayuda
  • Arabic
  • Chinese (simplified)
  • Chinese (traditional)
  • Aide
  • Asistans
  • Korean
  • Assistência
  • Russian
  • Tulong
  • Vietnamese
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshot
  • Grants
  • No FEAR Act Data
  • Plain Writing
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data
  • Inspector General
  • Jobs
  • Newsroom
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.