Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures Informational Webinar
Date and Time
1:00 pm - 2:00 pm EDT
Registration Deadline
Location
United States
Event Host
Event Type
Description
Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures Request for Applications and Informational Webinar
Open Date: October 8, 2021
Close Date: December 8, 2021
Background:
The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications focused on improving the quantitative evaluation of risks posed by chemical mixtures in the environment. The focus should be on the development and improvement, evaluation, and integration of predictive toxicology methods to evaluate environmental chemical mixtures. This new funding opportunity is titled Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures Request for Applications (RFA).
People are continually exposed to multiple chemicals present in the environment, including in air, water, soil, food, and products in commerce. Thousands of chemicals exist with minimal risk assessment-relevant information and there is a near infinite number of possible combinations of chemical mixtures like PFAS, phthalates, polycyclic aromatic hydrocarbons (PAHs), disinfection by-products (DBPs) or other well-characterized mixtures. These factors make it challenging to assess the toxicity of chemical mixtures. When assessing chemical mixtures, researchers have typically relied on information obtained from traditional experimental animal studies and/or human epidemiological exposure-response data on individual component chemicals.
This RFA is intended to address the number of hazards and the associated human health risks of exposures to chemical mixtures found in the environment.
Applications should address at least one of the following two research areas:
- Development and application of approaches to establish qualitative membership of chemical mixture components into toxicity pathway groupings, in order to quantitatively evaluate their potential joint toxicity.
- Development of methods and tools useful for the examination of chemical mixture toxicity across different levels of biological organization. Specifically, research is needed on how New Approach Methodologies (NAMs) data/outputs on differing levels of biological organization (e.g., from cellular to whole organism level) intended to discern toxicity or bioactivity of individual mixture components can relate back to their originating (i.e., exposure source) mixtures, and to final whole organism health effects.
For information on eligibility, project specifications, or how to apply, visit: Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures
Learn more about the Chemical Safety for Sustainability research program.
Learn more about EPA Research Grants.
Register for the Informational Webinar
Date: October 21, 2021
Time: 1:00 p.m. – 2:00 p.m. ET
Join us for an informational webinar on this funding opportunity. The webinar will cover application information and provide an overview of what has already been provided in the RFA.
Webinar Objectives:
- Share general information and information on research areas for the RFA (EPA Project Officer)
- Learn about the submission, eligibility, relevancy review and peer review processes (EPA Eligibility, Submission, and Peer Review Officers)
- Question & answer session
A copy of the webinar presentation will be available on the RFA webpage for those unable to participate in the scheduled webinar.