Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures Request for Applications (RFA)
COVID-19 Update: EPA is providing flexibilities to applicants experiencing challenges related to COVID-19. Please see the Flexibilities Available to Organizations Impacted by COVID-19 clause in Section IV of EPA’s Solicitation Clauses.
OVERVIEW INFORMATION
U.S. Environmental Protection Agency
Office of Science Advisor, Policy and Engagement
Office of Research and Development
Science to Achieve Results (STAR) Program
Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures
This is the initial announcement of this funding opportunity.
Funding Opportunity Numbers:
EPA-G2022-STAR-A1, Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures
EPA-G2022-STAR-A2, Early Career: Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures
Catalog of Federal Domestic Assistance (CFDA) Number: 66.509
Solicitation Opening Date: October 8, 2021
Solicitation Closing Date: December 8, 2021: 11:59:59 pm Eastern Time
This Request for Applications (RFA) solicits research focused on the development and evaluation of innovative methods and approaches to inform human health risk assessment of environmental chemical mixtures. Because most of the human chemical body burden involves concurrent or sequential exposures to mixtures of chemicals, methods to make better-informed, timelier evaluations of chemical mixtures of known, or partially-known, composition have long been needed. A challenge in conducting mixtures assessment is the lack of useful hazard and dose response data and other information on chemical mixtures. Potential chemical mixtures exposures of public health concern typically encountered in environmental media may include classes or subclasses of compounds (for example, per- and polyfluoroalkyl substances [PFAS], phthalates, polycyclic aromatic hydrocarbons [PAHs], disinfection by-products [DBPs]), or any other well-characterized mixtures. Applications are being sought that propose approaches and strategies that integrate in vitro, in silico, and/or non-mammalian in vivo methods that can contribute to decision-making science associated with toxicity evaluation and human health assessment of chemical mixtures.
Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures Webinar - October 21, 2021
Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures Webinar Q&A (pdf)